review: Mass spectrometric strategies for the investigation of biomarkers of illicit drug use in wastewater
Felix Hernandez, Sara Castiglioni, Adrian Covaci, Pim de Voogt, Erik Emke, Barbara Kasprzyk-Hordern, Christoph Ort, Malcolm Reid, Juan V. Sancho, Kevin V. Thomas, Alexander L.N. van Nuijs, Ettore Zuccato and Lubertus Bijlsma.
The article focuses on the potential of high-resolution mass spectrometry. Different approaches for target and non-target analysis are discussed, and the interest to perform experiments under laboratorycontrolled conditions, as a complementary tool to investigate related compounds (e.g., minor metabolites and/or transformation products in wastewater) is treated. The article ends up with the trends and future perspectives in this field from the authors’ point of view.